Direct Biologics
Direct Biologics is a biotechnology company developing investigational therapies using extracellular vesicles derived from adult bone marrow mesenchymal stem cells. The company has raised $116 million, including a Series B round in October 2022.
The growth story
Direct Biologics grew from 62 to 58 employees between 2022 and 2026, raising $116M along the way, most recently a Series B in October 2022.
About
Direct Biologics focuses on advancing clinical research programs for secretome-based products, which include extracellular vesicles derived from mesenchymal stem cells. These investigational therapies are being studied for their potential effects on immune and inflammatory pathways, with manufacturing conducted under cGMP standards.
The company, founded in 2017, has grown to 58 employees and secured $116 million in funding, most recently closing a Series B round in October 2022. Its research-driven approach targets regenerative medicine applications, supported by a focus on safety, innovation, and quality.
Founders and leadership
Direct Biologics is led by a team focused on research and development, with the largest function being Research, which includes seven employees. The company maintains a median tenure of three years, indicating stable leadership and staff retention.
The Direct Biologics org chart
John Constantine (Co-Founder) leads 27 mapped leaders with 4 direct reports. Click +N to expand a team; names link to the person’s public profile.
Departments, and which ones grew
Headcount by function: Research 12 (0% YoY), Operations 7 (0% YoY), Business Development 6 (+20% YoY), Legal 5 (0% YoY), Quality Assurance 4 (0% YoY), Engineering 3 (+200% YoY).
Talent flow
Employees at Direct Biologics often come from major pharmaceutical and biotechnology companies, including Baxter International, GSK, Johnson & Johnson, Biogen, and Merck. Alumni have moved to roles in companies like Future Medical Products and Abzena, with some retiring.
Most common previous employers of Direct Biologics staff: Baxter International (3), SCPX (3), GSK (2), Johnson & Johnson (2), Biogen (2), Merck (2). Former Direct Biologics employees most often moved to Retired (2), Future Medical Products (2), LEIDER CAPITAL (1), ZoHelpers (1), RapidSOS (1), Abzena (1).
Alumni worth knowing
The Direct Biologics mafia
Direct Biologics alumni have founded companies such as LEIDER CAPITAL, Aspen BioGroup, and NXTLVL, with multiple staff members contributing to these ventures.
3Stephen Leider, was Board Advisor until 2025Adam McQueen, MBA, was Sr. VP until 2022Paul Blazek, was Investor until 2019Web traffic
Traffic mix: 0% direct, 0% search, 0% social, 0% paid.
What this company is made of
Most common skills at Direct Biologics: Leadership (19), Biotechnology (17), Management (17), Microsoft Office (13), Project Management (13), Microsoft Excel (13), Good Manufacturing Practice (GMP) (12), Cross-functional Team Leadership (11).
Where the team actually sits
Direct Biologics people are concentrated in Texas, United States (16), California, United States (8), United States (3), Greater St. Louis (2).
Search footprint
Direct Biologics attracts about 259 organic search visits a month, traffic worth roughly $3K a month if bought through ads. It gained 33 ranking keywords and lost 37 in the last period.
What employees say
- Compensation
- 3.40 / 5
- Career opportunities
- 3.30 / 5
- Senior management
- 3.10 / 5
- Work-life balance
- 3.50 / 5
Frequently asked
Direct Biologics has 58 employees as of September 2026.
Direct Biologics has raised $116M in total, most recently a Series B round in October 2022.
Direct Biologics was founded in 2017 by Joe Schmidt, John Constantine.
John Constantine (Co-Founder) sits at the top of Direct Biologics's reporting structure, with 4 direct reports.
The most common previous employers of current Direct Biologics staff are Baxter International (3 people), SCPX (3 people), GSK (2 people).
Former Direct Biologics employees most often move to Retired (2), Future Medical Products (2), LEIDER CAPITAL (1).
At least 3 companies have a founder who previously worked at Direct Biologics, including LEIDER CAPITAL, Aspen BioGroup, NXTLVL.
Direct Biologics attracts about 259 organic search visits a month, worth roughly $3K a month in equivalent ad spend.
The most common skills among Direct Biologics staff are Leadership, Biotechnology, Management, Microsoft Office, Project Management.
Direct Biologics staff are concentrated in Texas, United States (16), California, United States (8), United States (3).
Direct Biologics has about 12 people in Research, up 0% over the past year, as of September 2026.
Direct Biologics has about 7 people in Operations, up 0% over the past year, as of September 2026.
Computed from 45 current and 81 former Direct Biologics profiles, as of September 2026. Source: Crustdata.
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