Upstream Bio
Upstream Bio is a clinical-stage biotech developing verekitug, a monoclonal antibody for severe inflammatory diseases, with $408M in total funding. The 83-person company raised a Series B in June 2023.
The growth story
Upstream Bio grew from 2 to 83 employees between 2021 and 2026, raising $408M along the way, most recently a Series B in June 2023.
About
Upstream Bio is developing verekitug, a monoclonal antibody that targets an upstream driver of inflammation. The drug is in clinical trials for severe inflammatory diseases, aiming to improve treatment options for patients.
The company has raised $408M, including a Series B in June 2023. Its 83-person team draws heavily from major biopharma firms, with Biogen and Sanofi being the top talent sources.
Founders and leadership
Operations is the largest function with 11 staff. The leadership team includes veterans from major biopharma companies, reflecting the company's focus on clinical development.
The Upstream Bio org chart
Rand Sutherland (Chief Executive Officer) leads 60 mapped leaders with 8 direct reports. Click +N to expand a team; names link to the person’s public profile.
Departments, and which ones grew
Headcount by function: Research 19 (+27% YoY), Healthcare Services 11 (+57% YoY), Quality Assurance 9 (+50% YoY), Operations 8 (+33% YoY), Business Development 8 (-20% YoY), Legal 5 (0% YoY).
Talent flow
Upstream Bio recruits heavily from Biogen (10 hires) and Sanofi (7 hires). Alumni have gone on to roles at Oblenio Bio, Omega Funds, and AstraZeneca.
Most common previous employers of Upstream Bio staff: Biogen (10), Sanofi (7), Shire (4), Translate Bio (4), Pfizer (4), Moderna (4). Former Upstream Bio employees most often moved to Oblenio Bio (2), Omega Funds (1), Autoimmunity BioSolutions (1), AstraZeneca (1), Venrock (1), Deciphera Pharmaceuticals (1).
Alumni worth knowing
Hiring now
Web traffic
Traffic mix: 0% direct, 0% search, 0% social, 0% paid.
What this company is made of
Most common skills at Upstream Bio: Microsoft Office (28), Clinical Trials (27), Biotechnology (26), Clinical Research (24), Microsoft Excel (22), Pharmaceutics (21), Good Clinical Practice (GCP) (20), Project Management (19).
Where the team actually sits
Upstream Bio people are concentrated in Massachusetts, United States (26), Greater Boston (23), United States (10), New Jersey, United States (1).
Search footprint
Upstream Bio attracts about 211 organic search visits a month, traffic worth roughly $0K a month if bought through ads. It gained 33 ranking keywords and lost 31 in the last period.
Frequently asked
Upstream Bio has 83 employees as of September 2026.
Upstream Bio has raised $408M in total, most recently a Series B round in June 2023.
Upstream Bio was founded in 2021 by Oren Becker, Eran Perry.
Rand Sutherland (Chief Executive Officer) sits at the top of Upstream Bio's reporting structure, with 8 direct reports.
The most common previous employers of current Upstream Bio staff are Biogen (10 people), Sanofi (7 people), Shire (4 people).
Former Upstream Bio employees most often move to Oblenio Bio (2), Omega Funds (1), Autoimmunity BioSolutions (1).
Upstream Bio attracts about 211 organic search visits a month, worth roughly $0K a month in equivalent ad spend.
The most common skills among Upstream Bio staff are Microsoft Office, Clinical Trials, Biotechnology, Clinical Research, Microsoft Excel.
Upstream Bio staff are concentrated in Massachusetts, United States (26), Greater Boston (23), United States (10).
Upstream Bio has about 19 people in Research, up 27% over the past year, as of September 2026.
Upstream Bio has about 11 people in Healthcare Services, up 57% over the past year, as of September 2026.
Computed from 74 current and 28 former Upstream Bio profiles, as of September 2026. Source: Crustdata.
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