Metagenomi Therapeutics
Metagenomi Therapeutics is a biotech startup developing genome editing tools from natural microbial DNA, with $467M in funding and 149 employees. Its Series B in January 2023 included pharma backers like Bayer and Bristol-Myers Squibb.
The growth story
Metagenomi Therapeutics grew from 58 to 149 employees between 2021 and 2026, raising $467M along the way, most recently a Series B in January 2023.
About
The company engineers gene-editing enzymes discovered through metagenomics, the study of DNA from uncultured environmental microbes. Its tools aim to enable edits currently impossible with CRISPR-based systems, targeting therapeutic applications.
With 52 researchers in its 149-person team, Metagenomi has raised $467M, including from strategic investors like Bayer. Nearly 10% of analyzed alumni went to Profluent, another gene-editing startup.
Founders and leadership
Research accounts for over a third of staff (52 employees). The company draws heavily from UC Berkeley, where co-founder Brian Thomas did his PhD, and biopharma firms like Genentech.
The Metagenomi Therapeutics org chart
Jian Irish, Ph.D, MBA (President and CEO) leads 40 mapped leaders with 9 direct reports. Click +N to expand a team; names link to the person’s public profile.
Departments, and which ones grew
Headcount by function: Research 69 (-26% YoY), Operations 12 (-20% YoY), Information Technology 8 (-27% YoY), Business Development 8 (-43% YoY), Engineering 7 (-50% YoY), Quality Assurance 6 (0% YoY).
Talent flow
One in seven employees came from UC Berkeley, Bayer or Genentech. Alumni frequently move to other gene-editing startups, with Profluent hiring six former staff.
Most common previous employers of Metagenomi Therapeutics staff: University of California, Berkeley (10), Gritstone bio (9), Bayer (8), Genentech (8), Boehringer Ingelheim (7), Amgen (6). Former Metagenomi Therapeutics employees most often moved to Profluent (6), Arc Institute (4), University of California, San Francisco (3), BioMarin Pharmaceutical (2), Benchling (2), MyOme (2).
Alumni worth knowing
The Metagenomi Therapeutics mafia
Four alumni founded companies, including Menlo Micro (76 staff) and three early-stage biotechs.
4Risa Stack, Ph.D, was Board Member until 2024Lucas Bernales, was Product Management Specialist until 2022Luis Borges, was Chief Scientific Officer until 2024Lindsay Caldwell, was Vice President Human Resources until 2025Web traffic
Traffic mix: 0% direct, 0% search, 0% social, 0% paid.
What this company is made of
Most common skills at Metagenomi Therapeutics: Molecular Biology (53), Microsoft Word (49), Leadership (48), Microsoft PowerPoint (47), Polymerase Chain Reaction (PCR) (42), Biotechnology (42), Cell Culture (40), Research Skills (38).
Where the team actually sits
Metagenomi Therapeutics people are concentrated in California, United States (61), San Francisco Bay Area (45), United States (4), Massachusetts, United States (3).
Search footprint
Metagenomi Therapeutics attracts about 187 organic search visits a month, traffic worth roughly $0K a month if bought through ads. It gained 8 ranking keywords and lost 12 in the last period.
What employees say
- Compensation
- 3.80 / 5
- Career opportunities
- 3.00 / 5
- Senior management
- 2.40 / 5
- Work-life balance
- 4.40 / 5
Frequently asked
Metagenomi Therapeutics has 149 employees as of September 2026.
Metagenomi Therapeutics has raised $467M in total, most recently a Series B round in January 2023.
Jian Irish, Ph.D, MBA (President and CEO) sits at the top of Metagenomi Therapeutics's reporting structure, with 9 direct reports.
The most common previous employers of current Metagenomi Therapeutics staff are University of California, Berkeley (10 people), Gritstone bio (9 people), Bayer (8 people).
Former Metagenomi Therapeutics employees most often move to Profluent (6), Arc Institute (4), University of California, San Francisco (3).
At least 4 companies have a founder who previously worked at Metagenomi Therapeutics, including Menlo Micro, Dose, Artemia Therapeutics.
Metagenomi Therapeutics attracts about 187 organic search visits a month, worth roughly $0K a month in equivalent ad spend.
The most common skills among Metagenomi Therapeutics staff are Molecular Biology, Microsoft Word, Leadership, Microsoft PowerPoint, Polymerase Chain Reaction (PCR).
Metagenomi Therapeutics staff are concentrated in California, United States (61), San Francisco Bay Area (45), United States (4).
Metagenomi Therapeutics has about 69 people in Research, down 26% over the past year, as of September 2026.
Metagenomi Therapeutics has about 12 people in Operations, down 20% over the past year, as of September 2026.
Computed from 117 current and 199 former Metagenomi Therapeutics profiles, as of September 2026. Source: Crustdata.
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