Profluent
Profluent is an AI-driven protein design company that has raised $150M in funding. Founded in 2022, it employs 78 people focused on developing generative models for novel protein design.
The growth story
Profluent grew from 12 to 78 employees between 2022 and 2026, raising $150M along the way, most recently a Series B in November 2025.
About
Profluent uses AI to design and validate functional proteins, aiming to advance biomedicine. Its technology leverages deep generative models to create novel protein structures.
The company has raised $150M in funding, including a Series B round in 2025. With 78 employees, Profluent is building its team around research, which accounts for 28 of its roles.
Founders and leadership
Profluent’s largest function is research, with 28 employees dedicated to this area. The company is led by a team focused on AI and biotechnology, supported by investors like Insight Partners and Bezos Expeditions.
The Profluent org chart
Ali Madani (Founder, CEO) leads 23 mapped leaders with 6 direct reports. Click +N to expand a team; names link to the person’s public profile.
Departments, and which ones grew
Headcount by function: Research 35 (+75% YoY), Engineering 13 (+86% YoY), Business Development 11 (+38% YoY), Operations 5 (+67% YoY).
Talent flow
Profluent’s team draws heavily from UC Berkeley, Zymergen, and UC San Francisco. Alumni have moved to companies like Eli Lilly and Turing, though turnover appears high with a median tenure of just one year.
Most common previous employers of Profluent staff: University of California, Berkeley (9), Zymergen (9), University of California, San Francisco (8), Metagenomi Therapeutics (6), Ginkgo Bioworks (5), Salesforce (3). Former Profluent employees most often moved to Eli Lilly and Company (1), Turing (1), Converge Bio (1), Lila Sciences (1), ICSI - International Computer Science Institute (1), Johns Hopkins Whiting School of Engineering (1).
Web traffic
Traffic mix: 22% direct, 69% search, 2% social, 0% paid.
What this company is made of
Most common skills at Profluent: Research Skills (31), Python (Programming Language) (30), Molecular Biology (22), Data Analysis (22), Microsoft Office (21), Machine Learning (19), Communication (16), R (Programming Language) (15).
Where the team actually sits
Profluent people are concentrated in California, United States (40), San Francisco Bay Area (9), United States (5), Greater Boston (2).
Search footprint
Profluent attracts about 81 organic search visits a month, traffic worth roughly $0K a month if bought through ads. It gained 19 ranking keywords and lost 6 in the last period.
What employees say
- Compensation
- 4.00 / 5
- Career opportunities
- 3.00 / 5
- Senior management
- 4.00 / 5
- Work-life balance
- 2.00 / 5
Frequently asked
Profluent has 78 employees as of September 2026.
Profluent has raised $150M in total, most recently a Series B round in November 2025.
Profluent was founded in 2022 by Ali Madani.
Ali Madani (Founder, CEO) sits at the top of Profluent's reporting structure, with 6 direct reports.
The most common previous employers of current Profluent staff are University of California, Berkeley (9 people), Zymergen (9 people), University of California, San Francisco (8 people).
Former Profluent employees most often move to Eli Lilly and Company (1), Turing (1), Converge Bio (1).
Profluent attracts about 81 organic search visits a month, worth roughly $0K a month in equivalent ad spend.
The most common skills among Profluent staff are Research Skills, Python (Programming Language), Molecular Biology, Data Analysis, Microsoft Office.
Profluent staff are concentrated in California, United States (40), San Francisco Bay Area (9), United States (5).
Profluent has about 35 people in Research, up 75% over the past year, as of September 2026.
Profluent has about 13 people in Engineering, up 86% over the past year, as of September 2026.
Computed from 65 current and 13 former Profluent profiles, as of September 2026. Source: Crustdata.
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